A primary hepatic malignancy of cholangiocellular origin.

LI-RADS Categorization:

• Observations thought to represent intrahepatic cholangiocarcinoma (ICC) should be categorized LR-M.

Comments:

• ICC is the second most common malignancy in patients with cirrhosis or other risk factors for HCC.
• Differentiation between HCC and ICC is important as the management and prognosis differ. In general, patients with ICC should not undergo liver transplant, due to unacceptably high post-transplant recurrence risk.